Biuron

Program · BIO·03

Living Systems Models

We train models on the behaviour of living systems, cells, proteins, and the molecular machinery between them, learning the rules of biology to accelerate medicine and molecular design. Biology is the richest dataset we have, and we treat it as one.

ProgramBIO·03
DisciplineCell biology · Molecular design · Imaging
Publications2
StatusActive

What we work on

A program is a small set of hard, coupled problems. These are the ones this group is working on now.

01Foundation models of cellular dynamics
02Protein structure and interaction prediction
03In-silico perturbation and phenotype search
04Live-cell imaging at scale
01

The cell as a learnable system

A cell is a computer we did not design. By training on millions of live-cell trajectories, we build models that predict how a cell will respond to a perturbation before it happens, turning the wet lab from a place of discovery into a place of confirmation.

02

From sequence to behaviour

Structure prediction told us what proteins look like. The next question is what they do, in context, in a pathway, under stress. We model the behaviour, not just the shape, connecting molecular events to cellular outcomes.

03

Search where experiment cannot reach

The space of possible molecules is vastly larger than any lab can test. Models that have learned biology's rules let us search that space in silico, surfacing the few candidates worth the bench.

Signals from the program

2.1M
live-cell trajectories in the training set
3.1M
candidate molecules screened in silico
10×
target speed-up in hit-to-lead

Selected writing from this program

← Previous program · AGT·02Reasoning & AssistantsNext program · NEU·04Neural Computation

Collaborate

Work on this with us.

We hire researchers and engineers who want to push one of these programs forward, and partners who want to put the results to work.